This module is to understand the basics of Specific Optical Rotation (SOR) and principle of polarimetry. It gives and an overview of the components and operation of a polarimeter.
|Who is it for||
Personnel in production, analytical quality, including quality control and quality assurance who use this technique should complete this module.
|Why it matters||
Many pharmaceutical substances are optically active because of the presence of one or more asymmetric centers, usually a carbon atom with four different substituents, resulting in many isomers. Polarimetry is perhaps the only convenient means for distinguishing optically active isomers from each other. As such, it is an important identification and purity measurement for QC analysts.